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Molecular Cancer Research 1:882-891 (2003)
© 2003 American Association for Cancer Research

Cancer Genes and Genomics

Reduced Accumulation of Specific MicroRNAs in Colorectal Neoplasia1

Michael Z. Michael1,2, Susan M. O' Connor2, Nicholas G. van Holst Pellekaan2, Graeme P. Young2 and Robert J. James1

1 Department of Gastroenterology and Hepatology, Flinders Centre for Digestive Health, Flinders Medical Centre, South Australia, Australia and
2 Department of Medicine, Flinders University of South Australia, Australia

Requests for reprints: Michael Z. Michael, Flinders Medical Centre, Gastroenterology and Hepatology (Room 3D230), Flinders Drive, Bedford Park, South Australia 5042, Australia. Phone: 61-8-8204-3940; Fax: 61-8-8204-3943. E-mail: michael.michael{at}flinders.edu.au

Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin formation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia.

Key Words: colorectal cancer • gene expression • microRNA • epigenetics • RNA interference




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